Endogenous Activation of Kainate Receptors Regulates Glutamate Release and Network Activity in the Developing Hippocampus
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چکیده
منابع مشابه
Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus.
Kainate receptors (KARs) are highly expressed throughout the neonatal brain, but their function during development is unclear. Here, we show that the maturation of the hippocampus is associated with a switch in the functional role of presynaptic KARs. In a developmental period restricted to the first postnatal week, endogenous L-glutamate tonically activates KARs at CA3 glutamatergic synapses t...
متن کاملKainate-type Glutamate Receptors Modulating Network Activity in Developing Hippocampus
viii 1 Review of the literature 1 1.2 Development of hippocampal network 2 1.3 Properties of kainate receptors 5 1.3.1 Structure 5 1.3.3 Pharmacology 10 1.3.2 Signaling 8 1.4 Kainate receptors in immature hippocampus 12 1.4.1 Expression 12 1.4.2 Functions 14 1.4.3 Role in network activity 18 1.5 Ethanol and the developing hippocampus 21 2 Aims 24 3 Materials and methods 25 3.1 Preparation of ac...
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Presynaptic kainate receptors regulate synaptic transmission in several brain areas but are not known to have this action at immature mossy fiber (MF) terminals, which during the first week of postnatal life release GABA, which exerts into targeted cells a depolarizing and excitatory action. Here, we report that, during the first week of postnatal life, endogenous activation of GluK1 receptors ...
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اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4050-04.2005